Nicked β2-glycoprotein I binds angiostatin 4.5 and attenuates its anti-angiogenic property
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چکیده
منابع مشابه
VASCULAR BIOLOGY Nicked 2-glycoprotein I binds angiostatin 4.5 (plasminogen kringle 1-5) and attenuates its antiangiogenic property
Angiostatin was first discovered as a plasminogen fragment with antitumor/antiangiogenic property. One of the angiostatin isoforms, that is, angiostatin 4.5 (AS4.5), consisting of plasminogen kringle 1 to 4 and a most part of kringle 5, is produced by autoproteolysis and present in human plasma. 2-glycoprotein I ( 2GPI) is proteolytically cleaved by plasmin in its domain V (nicked 2GPI), result...
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ژورنال
عنوان ژورنال: Japanese Journal of Thrombosis and Hemostasis
سال: 2010
ISSN: 1880-8808,0915-7441
DOI: 10.2491/jjsth.21.314